These immune cytopenias may occur simultaneously or sequentially. In the initial description by evans et al in 1951, the anemia and thrombocytopenia varied with respect to time of onset, course, and duration. Evans, syndrome, hemolytic anemia, thrombocytope nia, neutropenia. Previously, it was known as the simultaneous or sequential development of primary immune thrombocytopenia and autoimmune hemolytic anemia 2. Evans syndrome is the coexistence of simultaneous or sequential direct coombspositive autoimmune hemolytic anemia aiha with immunemediated thrombocytopenia. Etiology evans syndrome is an autoimmune disorder in which noncrossreacting autoantibodies are targeted towards different antigenic determinants on red cells, platelets, sometimes neutrophils. Although few statistical data are available, it has been reported that between and 73% of patients with autoimmune hemolytic. Our patient is a girl 10 month old with evanss syndrome, lymphopenia, antinuclear antibodies, antidna antibodies, lupus anticoagulant and anticardiolipin antibodies. E uma doenca cronica e recidivante associada a morbidade significativa, apesar da terapeutica. This familial disease is associated with a high lifetime risk of esophageal cancer. Alguns pacientes com esta doenca podem ter apenas as celulas brancas destruidas ou apenas as celulas vermelhas, mas toda a. Management of evans syndrome uw hematology protocols. Howelevans syndrome is an extremely rare condition involving thickening of the skin in the palms of the hands and the soles of the feet hyperkeratosis.
Systemic lupus erythematosus and antiphospholipid syndromes are infrequent conditions in children under 5 years. Evans syndrome, thrombocytopenia, autoimmune hemolytic anemia, pregnancy. Evans syndrome is a rare diagnosis although the exact frequency is unknown. Surge quando os anticorpos produzidos pelo corpo atacam o. May 29, 2019 please use one of the following formats to cite this article in your essay, paper or report. Evans syndrome in patients with secondary antiphospholipid.